Product Details
FireProt-ASR
Created: 2019
Czech title
FireProt-ASR
Type
software
License
optional - free
Authors
Musil Miloš, Ing., Ph.D. (DIFS FIT BUT)
Khan Rayyan T., M.Sc. (LL)
Beier Andy, Dr. (LL)
Štourač Jan (LL)
Konegger Hannes (LL)
Damborský Jiří, prof. Mgr., Dr. (LL)
Bednář David, Mgr. (LL)
Khan Rayyan T., M.Sc. (LL)
Beier Andy, Dr. (LL)
Štourač Jan (LL)
Konegger Hannes (LL)
Damborský Jiří, prof. Mgr., Dr. (LL)
Bednář David, Mgr. (LL)
Keywords
protein engineering, thermostable proteins, ancestral sequence reconstruction, evolutionary design, protein stability
Description
FireProt-ASR is a web server for an automated calculation of ancestral sequences. Fireprot-ASR allows users to perform ancestral sequence reconstruction starting from a single protein sequence. The pipeline first compiles a dataset of catalytically similar protein sequences, reduces the starting dataset to the required size, aligns them, construct their phylogenetic tree, and then reconstruct ancestral nodes together with the correction of the ancestral gaps. It also allows user to input their own data and start from a different point in the pipeline.
Projects
ICT tools, methods and technologies for smart cities (FIT-S-17-3964)
Research groups
Departments