Course details


IV108 Acad. year 2018/2019 Winter semester

Current academic year

An advanced course in bioinformatics (lecture and computer lab) building upon elementary mol.biology and/or bioinformatics courses.


Lexa Matej, Ing., Ph.D. (FI MUNI)

Language of instruction



Examination (oral)

Time span

13 hrs lectures, 13 hrs exercises

Assessment points

100 exam


Lexa Matej, Ing., Ph.D. (FI MUNI)

Syllabus of lectures

1. Biological language (sequence segmentation, information-statistical analysis of biological sequences)
2. Pattern matching (algoritms based on filtration and suffix arrays)
3. Heuristic algorithms for similarity searching in biological sequences (BLAST, BLAT, Pattern Hunter)
4. Regular expressions in bioinformatics
5. Algorithms for analysis and prediction of structural data (secondary strukture, contacts inb proteins, domain identification)
6. Algorithms for analysis and prediction of structural data (3D structure, structural comparisons)
7. Working with molecular structures in Pymol
8. New methods of DNA sequencing
9. Genome assembly and other operations on short nucleic acid sequences
10. Prediction of melting temperature in DNA and other nucleic acids (program mfold)
11. RNA secondary structure
12. DNA computing
13. Comparative genomics of human (analysis of scientific papers)

Course inclusion in study plans

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