Course details

Advanced Bioinformatics

PBI Acad. year 2018/2019 Winter semester 4 credits

Current academic year

During the lectures, the students will get acquainted with areas integrating different bioinformatic data-types. They will study possibilities of data integration to solve specific problems or create specific computational tools. Textbook material will be supplemented by recently published scientific papers. Students will work on individual computational modules in the exercises/projects leading to the creation of an integrated whole-class tool suitable for general bioinformatic analysis (functional annotation, structural prediction, molecule visualization).

Guarantor

Lexa Matej, Ing., Ph.D. (FI MUNI)

Language of instruction

Czech

Completion

Examination (written+oral)

Time span

20 hrs lectures, 13 hrs pc labs, 6 hrs projects

Assessment points

51 exam, 29 labs, 20 projects

Department

DCSY FIT BUT

Lecturer

Lexa Matej, Ing., Ph.D. (FI MUNI)

Instructor

Lexa Matej, Ing., Ph.D. (FI MUNI)
Puterová Janka, Ing. (DIFS FIT BUT)

Subject specific learning outcomes and competences

Knowledge of less-common algorithm and analysis methods, better ability to design and implement algorithms for bioinformatics.

Generic learning outcomes and competences

Deeper understanding the role of computers in the analysis and presentation of biological data.

Learning objectives

To build on the introductory bioinformatics course. Introduce the students to selected, fast-evolving, or otherwise noteworthy areas of bioinformatics. To allow space for creative activities resulting in the creation of a computational tool based on studied principles.

Study literature

  • Jones N.C., Pevzner P.: An introduction to algorithms in bioinformatics. MIT Press, 2004, ISBN 978-0262101066

Fundamental literature

Syllabus of lectures

  1. Introduction
  2. Primary and derived bioinformatic data
  3. Genomes and genome analysis methods
  4. Uniprot and sequence analysis methods
  5. Statistical, information-theory and linguistic aspect of data
  6. Coding algorithms for biological sequence analysis
  7. PDB and structural data analysis
  8. Gene Ontology and functional data analysis
  9. Integration of data from multiple sources for genomics and proteomics
  10. Tools and libraries for software development (Biopython)
  11. Visualization tools (PyMol)
  12. Bioinformatics and nanotechnology: DNA computing, sequencing by hybridization
  13. Recent trends

Syllabus of computer exercises

  1. Biological sequence analysis
  2. Genome Browser, Biomart
  3. Biopython a PyMol
  4. R/Bioconductor
  5. Integration of bioinformatic data

Syllabus - others, projects and individual work of students

Design and implementation of an integrated computational tool for bioinformatics and its presentation on a mini-conference.

Progress assessment

Project, computer labs assignments.

Exam prerequisites

None.

Course inclusion in study plans

  • Programme IT-MSC-2, field MBI, 2nd year of study, Compulsory
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