Course details

Molecular Genetics

MOG FCH BUT BC_MOG1 Acad. year 2021/2022 Winter semester 3 credits

History of molecular genetics. Genetic information and the genetic code. The molecular structure of the procaryotic and eucaryotic genome. Replication and transcription of the procaryotic and eucaryotic genome. Posttranscriptional modification and processing of RNA. Translation and posttranslational processing. Regulation of gene expression. Molecular basis of cancerogenesis (oncogenes, antioncogenes). Molecular mechanisms of mutagenesis and recombination. Mobile elements. Repair mechanisms of damaged DNA. Basic methods of molecular genetics. DNA cloning. Gene engineering and transgenic organisms.

Guarantor

Smetana Jan, Mgr., Ph.D. (UCHPBT FCH VUT)

Language of instruction

Czech

Completion

Examination (written+oral)

Time span

26 hrs lectures

Assessment points

100 exam

Department

Lecturer

Subject specific learning outcomes and competences

The basic knowledge of molecular biology, using methods of molecular biology and gene engineering in the research area, in industry, agriculture and medicine.

Generic learning outcomes and competences

The basic knowledge of molecular biology, using methods of molecular biology and gene engineering in the research area, in industry, agriculture and medicine.

Learning objectives

This lecture is conceived as an introduction into molecular biology and genetics and gives the explanation of processes on the molecular level in relation to the basic functions of living systems. The second part of the lecture is focused on basic methods of molecular genetics and their applications in gene engineering which is the main tool of modern biotechnologies.

Why is the course taught

Understanding the field which is not the main study component in a computer science-based study programme.

Prerequisite kwnowledge and skills

The structure and basic functions of living systems, their reproduction, cell chemistry, structure and function of biomacromolecules.

Study literature

  • Rosypal S. a kol.: Úvod do molekulární biologie. S. Rosypal, Brno 2006. (in Czech)
  • Watson, J.D. et al.: Recombinant DNA, W.H.Freeman, New York 1992.
  • Griffith, A.J.E.: An introduction to genetic analysis. W. H. Freeman and Comp., New York 2004.
  • Sundstad P., Simmons M.J. Genetika. Český překlad, Masarykova univerzita, Brno 2009 (in Czech)

Fundamental literature

  • Rosypal S. a kol.: Úvod do molekulární biologie. S. Rosypal, Brno 2006. (in Czech)
  • Watson, J.D. et al.: Recombinant DNA, W.H.Freeman, New York 1992.
  • Griffith, A.J.E.: An introduction to genetic analysis. W. H. Freeman and Comp., New York 2004.
  • Sundstad P., Simmons M.J. Genetika. Český překlad, Masarykova univerzita, Brno 2009 (in Czech)

Syllabus of lectures

History of molecular genetics. Genetic information and the genetic code. Molecular structure of procaryotic and eucaryotic genome. Replication and transcription of procaryotic and eucaryotic genome. Postranscriptional modification and processing of RNA. Translation and posttranslational processing. Regulation of gene expression. Molecular basis of cancerogenesis (oncogenes, antioncogenes). Molecular mechanisms of mutagenesis and recombination. Mobile elements. Repair mechanisms of damaged DNA. Basic methods of molecular genetics. DNA cloning. Gene engineering and transgenic organisms. Gene therapy. Genetic diseases and their diagnostics. Molecular genetics of plants and their use in agriculture.

Progress assessment

Lectures are optional, no control tests during the semester

Controlled instruction

The course uses teaching methods in form of Lecture - 2 teaching hours per week. The e-learning system (LMS Moodle) is available to teachers and students.

Oral exam.

Schedule

DayTypeWeeksRoomStartEndLect.grpGroupsInfo
Thulecturelectures P118/M66 08:0009:50 1MIT 2MIT xx Smetana

Course inclusion in study plans

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