Thesis Details

Predikce homologních sekvencí proteinů

Master's Thesis Student: Chlupová Hana Academic Year: 2014/2015 Supervisor: Martínek Tomáš, doc. Ing., Ph.D.
English title
Prediction of Homolog Protein Sequences
Language
Czech
Abstract

Prediction and searching for homologous protein sequences is one of important tasks which are currently being addressed in the area of bioinformatics. According to the determination of homologous sequences of unknown protein sequence it is often possible to determine its structure and function in the organism. For searching homologous sequences, the most frequently used tools are based on direct sequence comparison, profile comparison or on the use of hidden Markov models. There is no universal method better than all others. To satisfy user`s request on needed sequence identity between domains and error rate between founded true positive and false positive pairs, the selection of proper method and its settings is needed. This work is focused to create tool which will help user to choose the best method and its settings according to his requirements. It was created on the basis of the analysis of method results with different settings. In addition, the implemented  application offers the possibility to run this method and show its results.

Keywords

prediction of homology sequences, hidden Markov models, HMM, proteins.

Department
Degree Programme
Information Technology, Field of Study Bioinformatics and Biocomputing
Files
Status
defended, grade B
Date
22 June 2015
Reviewer
Committee
Sekanina Lukáš, prof. Ing., Ph.D. (DCSY FIT BUT), předseda
Bartík Vladimír, Ing., Ph.D. (DIFS FIT BUT), člen
Martínek Tomáš, doc. Ing., Ph.D. (DCSY FIT BUT), člen
Meduna Alexander, prof. RNDr., CSc. (DIFS FIT BUT), člen
Steingartner William, Ing., Ph.D. (TUKE), člen
Zbořil František, doc. Ing., Ph.D. (DITS FIT BUT), člen
Citation
CHLUPOVÁ, Hana. Predikce homologních sekvencí proteinů. Brno, 2015. Master's Thesis. Brno University of Technology, Faculty of Information Technology. 2015-06-22. Supervised by Martínek Tomáš. Available from: https://www.fit.vut.cz/study/thesis/17336/
BibTeX
@mastersthesis{FITMT17336,
    author = "Hana Chlupov\'{a}",
    type = "Master's thesis",
    title = "Predikce homologn\'{i}ch sekvenc\'{i} protein\r{u}",
    school = "Brno University of Technology, Faculty of Information Technology",
    year = 2015,
    location = "Brno, CZ",
    language = "czech",
    url = "https://www.fit.vut.cz/study/thesis/17336/"
}
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