Thesis Details
Shlukování biologických sekvencí
One of the main reasons for protein clustering is prediction ofstructure, function and evolution. Many of current tools have disadvantage ofhigh computational complexity due to all-to-all sequence alignment. If anytool works faster, it does not reach accuracy as other tools. Furtherdisadvantage is processing on higher rate of similarity but homologousproteins can be similar with less identity. The process of clustering oftenends when reach the condition which does not reflect sufficient quality ofclusters. Master's thesis describes the design and implementation of new toolfor clustering of protein sequences. New tool should not be computationallydemanding but it should preserve required accuracy and produce betterclusters. The thesis also describes testing of designed tool, evaluation ofresults and possibilities of its further development.
Clustering, biological sequence, protein, comparison, similarity, hierarchy, bioinformatics
Bartík Vladimír, Ing., Ph.D. (DIFS FIT BUT), člen
Martínek Tomáš, doc. Ing., Ph.D. (DCSY FIT BUT), člen
Meduna Alexander, prof. RNDr., CSc. (DIFS FIT BUT), člen
Steingartner William, Ing., Ph.D. (TUKE), člen
Zbořil František, doc. Ing., Ph.D. (DITS FIT BUT), člen
@mastersthesis{FITMT17338,
author = "Radim Kubi\v{s}",
type = "Master's thesis",
title = "Shlukov\'{a}n\'{i} biologick\'{y}ch sekvenc\'{i}",
school = "Brno University of Technology, Faculty of Information Technology",
year = 2015,
location = "Brno, CZ",
language = "czech",
url = "https://www.fit.vut.cz/study/thesis/17338/"
}