Thesis Details

Lokalizace metylačních míst transposonů

Master's Thesis Student: Kmeť Miroslav Academic Year: 2014/2015 Supervisor: Vogel Ivan, Ing.
English title
Localization of Methylation Sites in Transposons
Language
Czech
Abstract

This master's thesis deals with the creation of a tool for the extraction of methylation level from transposon sequences. Transposons are DNA elements with ability to move or copy themselves and their activity is regulated by DNA methylation. Sequence methylation information is stored in the bisulfite data and their processing is done with parts of two existing tools in a combination with implemented modules. Created tool takes into consideration unique challenges brought in the methylation calling process by transposable elements and it's functionality is presented on a set of experiments with simulated and real data.

Keywords

transposons, methylation, DNA, bisulfite sequencing, next-generation sequencing, 3-letter mapping, methylation calling

Department
Department of Information Systems FIT BUT
Degree Programme
Information Technology, Field of Study Bioinformatics and Biocomputing
Files
Status
defended, grade B
Date
22 June 2015
Reviewer
Martínek Tomáš, doc. Ing., Ph.D.
Committee
Sekanina Lukáš, prof. Ing., Ph.D. (DCSY FIT BUT), předseda
Bartík Vladimír, Ing., Ph.D. (DIFS FIT BUT), člen
Martínek Tomáš, doc. Ing., Ph.D. (DCSY FIT BUT), člen
Meduna Alexander, prof. RNDr., CSc. (DIFS FIT BUT), člen
Steingartner William, Ing., Ph.D. (TUKE), člen
Zbořil František, doc. Ing., Ph.D. (DITS FIT BUT), člen
Citation
KMEŤ, Miroslav. Lokalizace metylačních míst transposonů. Brno, 2015. Master's Thesis. Brno University of Technology, Faculty of Information Technology. 2015-06-22. Supervised by Vogel Ivan. Available from: https://www.fit.vut.cz/study/thesis/17456/
BibTeX 
@mastersthesis{FITMT17456,
    author = "Miroslav Kme\v{t}",
    type = "Master's thesis",
    title = "Lokalizace metyla\v{c}n\'{i}ch m\'{i}st transposon\r{u}",
    school = "Brno University of Technology, Faculty of Information Technology",
    year = 2015,
    location = "Brno, CZ",
    language = "czech",
    url = "https://www.fit.vut.cz/study/thesis/17456/"
}

Theses

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