Publication Details

Full Modeling of High-Intensity Focused Ultrasound and Thermal Heating in the Kidney Using Realistic Patient Models

SUOMI Visa, JAROŠ Jiří, TREEBY Bradley E. and CLEVELAND Robin. Full modelling of high-intensity focused ultrasound and thermal heating in the kidney of realistic patient models. IEEE Transactions on Biomedical Engineering, vol. 65, no. 11, pp. 2660-2670. ISSN 0018-9294. Available from:
Czech title
Modelování ultrazvuku o vysoké intenzitě a jeho termálního působení na model ledvin reálných pacientů
journal article
Suomi Visa (UOx)
Jaroš Jiří, doc. Ing., Ph.D. (DCSY FIT BUT)
Treeby Bradley E. (UCL)
Cleveland Robin, prof., Ph.D. (UOx)

High-intensity focused ultrasound, kidney, simulation, aberration, phase shift


Objective: High-intensity focused ultrasound (HIFU) therapy can be used for non-invasive treatment of kidney (renal) cancer, but the clinical outcomes have been variable. In this study, the efficacy of renal HIFU therapy was studied using nonlinear acoustic and thermal simulations in three patients.
Methods: The acoustic simulations were conducted with and without refraction in order to investigate its effect on the shape, size and pressure distribution at the focus. The values for the attenuation, sound speed, perfusion and thermal conductivity of the kidney were varied over the reported ranges to determine the effect of variability on heating. Furthermore, the phase aberration was studied in order to quantify the underlying phase shifts using a second order polynomial function.
Results: The ultrasound field intensity was found to drop on average 11.1 dB with refraction and 6.4 dB without refraction. Reflection at tissue interfaces was found to result in a loss less than 0.1 dB. Focal point splitting due to refraction significantly reduced the heating efficacy. Of all the tissue parameters, perfusion was found to affect the heating the most. Small changes in temperature were seen with varying attenuation and thermal conductivity, but no visible changes were present with sound speed variations. The aberration study revealed an underlying trend in the spatial distribution of the phase shifts.
Conclusion: The results show that the efficacy of HIFU therapy in the kidney could be improved with aberration correction.
Significance: A method is proposed by which patient specific pre-treatment calculations could be used to overcome the aberration and therefore make ultrasound treatment possible.

IEEE Transactions on Biomedical Engineering, vol. 65, no. 11, ISSN 0018-9294
Institute of Electrical and Electronics Engineers
EID Scopus
   author = "Visa Suomi and Ji\v{r}\'{i} Jaro\v{s} and E. Bradley Treeby and Robin Cleveland",
   title = "Full Modeling of High-Intensity Focused Ultrasound and Thermal Heating in the Kidney Using Realistic Patient Models",
   pages = "2660--2670",
   journal = "IEEE Transactions on Biomedical Engineering",
   volume = 65,
   number = 11,
   year = 2018,
   ISSN = "0018-9294",
   doi = "10.1109/TBME.2018.2870064",
   language = "english",
   url = ""
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