Course details

Bioinformatics

IV108 Acad. year 2016/2017 Winter semester

Current academic year

An advanced course in bioinformatics (lecture and computer lab) building upon elementary mol.biology and/or bioinformatics courses.

Guarantor

Language of instruction

Czech, English

Completion

Examination (oral)

Time span

  • 13 hrs lectures
  • 13 hrs exercises

Assessment points

  • 100 pts final exam

Department

Subject specific learning outcomes and competences

Item has no knowledges.

Learning objectives

Item has no goals.

Prerequisite knowledge and skills

There are no prerequisites

Syllabus of lectures

1. Biological language (sequence segmentation, information-statistical analysis of biological sequences)
2. Pattern matching (algoritms based on filtration and suffix arrays)
3. Heuristic algorithms for similarity searching in biological sequences (BLAST, BLAT, Pattern Hunter)
4. Regular expressions in bioinformatics
5. Algorithms for analysis and prediction of structural data (secondary strukture, contacts inb proteins, domain identification)
6. Algorithms for analysis and prediction of structural data (3D structure, structural comparisons)
7. Working with molecular structures in Pymol
8. New methods of DNA sequencing
9. Genome assembly and other operations on short nucleic acid sequences
10. Prediction of melting temperature in DNA and other nucleic acids (program mfold)
11. RNA secondary structure
12. DNA computing
13. Comparative genomics of human (analysis of scientific papers)

Progress assessment

Study evaluation is based on marks obtained for specified items. Minimimum number of marks to pass is 50.

Controlled instruction

There are no checked study.

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