Faculty of Information Technology, BUT

Product Details

FireProt web

Created: 2016

Czech title
optional - free
Musil Miloš, Ing. (DIFS FIT BUT)
Štourač Jan (LL)
Bendl Jaroslav, Ing. (DIFS FIT BUT)
Brezovský Jan, Mgr., Ph.D. (LL)
Martínek Tomáš, Ing., Ph.D. (DCSY FIT BUT)
Zendulka Jaroslav, doc. Ing., CSc. (DIFS FIT BUT)
Prokop Zbyněk, doc. RnDr., Ph.D. (LL)
Bednář David, Mgr. (LL)
Damborský Jiří, prof. Mgr., Dr. (LL)
protein engineering, thermostable proteins, multiple-point mutants, protein stability
FireProt is a web server for an automated design of thermostable mutants. The design of thermostable mutants is based on integration of structural and evolutionary infromation obtained from several bioinfromatics databases and computational tools.
FireProt strategy combines energy and evolution based approaches together with several filters that accelerate the calculation by omitting potentially deleterious mutations. Within its workflow, FireProt integrates 16 computational tools, utilizing both sequence and structural information in the process. FIreProt web server provides users with a one-stop-shop solution for the design of thermostable proteins, constructed by three distinct strategies. Futhermore, the server allows users to include user-defined mutations into the constructed thermostable protein and generate corresponding sequences in the FASTA format.
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