Result Details

FireProt: web server for automated design of thermostable proteins

MUSIL, M.; MARTÍNEK, T.; ZENDULKA, J. FireProt: web server for automated design of thermostable proteins. DAZ & WIKT 2018 Proceedings. Brno: 2018. p. 1-4.
Type
conference paper
Language
English
Authors
Musil Miloš, Ing., Ph.D., DIFS (FIT)
Martínek Tomáš, doc. Ing., Ph.D., DCSY (FIT)
Zendulka Jaroslav, doc. Ing., CSc., DIFS (FIT)
Annotation

There is a continuous interest in increasing proteins stability to enhance their usability in numerous biomedical and biotechnological applications. Only a single-point mutations with a small impact on protein stability are typically predicted with the existing tools, while more complex multiple-point mutants are necessary for useful stabilization. Here, we present FireProt, a web server for automated design of multiplepoint thermostable mutants that combines structural and evolutionary information in its calculation core. The server is complemented with interactive, easy-to-use interface that allows users to directly analyze and optionally modify designed thermostable mutants.

Published
2018
Pages
1–4
Proceedings
DAZ & WIKT 2018 Proceedings
Conference
Data a znalosti 2018
Place
Brno
BibTeX 
@inproceedings{BUT169466,
  author="Miloš {Musil} and Tomáš {Martínek} and Jaroslav {Zendulka}",
  title="FireProt: web server for automated design of thermostable proteins",
  booktitle="DAZ & WIKT 2018 Proceedings",
  year="2018",
  pages="1--4",
  address="Brno",
  url="https://www.fit.vut.cz/research/publication/11818/"
}
Files
Projects
Nástroje, metody a technologie ICT pro podporu konceptu smart cities, BUT, Vnitřní projekty VUT, FIT-S-17-3964, start: 2017-03-01, end: 2020-02-29, completed
Departments
Department of Information Systems (DIFS)
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